Seasonality of coastal upwelling trends in the Mauritania-Senegalese region under RCP8.5 climate change scenario.

The Mauritania-Senegalese upwelling region (MSUR), the southernmost region of the Canary current upwelling system, is well-known for its coastal productivity and the key role it plays in enriching the oligotrophic open ocean through the offshore transport of the upwelled coastal waters. The great ecological and socio-economic importance makes it necessary to evaluate the impact of climate change on this region. Hence, our main objective is to examine the climate change signal over the MSUR with a high resolution regional climate system model (RCSM) forced by the Earth system model MPI-ESM-LR under RCP8.5 scenario. This RCSM has a regional atmosphere model (REMO) coupled to a global ocean model (MPIOM) with high-resolution in the MSUR, which allows us to evaluate the wind pattern, the ocean stratification, as well as the upwelling source water depth, while maintaining an ocean global domain. Under RCP8.5 scenario, our results show that the upwelling favourable winds of the northern MSUR are year-round intensified, while the southern MSUR presents a strengthening in winter and a weakening in March-April. Along with changes in the wind pattern, we found increased ocean stratification in the spring months. In those months southern MSUR presents a shallowing of the upwelling source water depth associated to changes in both mechanisms. However, in winter the whole MSUR shows a deepening of the upwelling source water depth due to the intensification of the upwelling favourable winds, with the increased ocean stratification playing a secondary role. Our results demonstrate the need to evaluate the future evolution of coastal upwelling systems taking into account their latitudinal and seasonal variability and the joint contribution of both mechanisms.

Quiste óseo solitario / No disponible

INTRODUCCIÓN: El quiste óseo solitario representa el 1% de todos los quistes maxilares. Es una lesión ósea benigna que aparece de forma fortuita en una radiografía de control en la primera/segunda década de la vida, aunque la lesión carezca de trascendencia en la vida del paciente requiere de abordaje quirúrgico para confirmar el diagnóstico. CASO CLÍNICO: Se presenta un caso clínico de una paciente mujer de 11 años de edad y raza negra, remitida al Servicio de Cirugía Bucal del Hospital Virgen de la Paloma tras observarse imagen radiotransparente apical a nivel de 43 y 44. Una vez realizada la exploración clínica y radiológica se propone cirugía exploratoria ante diagnóstico de presunción de quiste óseo solitario. Bajo anestesia local se procedió al abordaje quirúrgico observándose cavidad vacía en maxilar inferior sin contenido alguno, legrándose profusamente las paredes de la cavidad e introduciendo plasma rico en plaquetas obtenido previamente de la paciente. CONCLUSIONES: La cirugía exploratoria confirma el diagnóstico de presunción de quiste óseo solitario vacío al no poderse mandar a analizar a anatomía patológica

No disponible

Impact of International Atomic Energy Agency support to the development of nuclear cardiology in low-and-middle-income countries: Case of Latin America and the Caribbean.

Cardiovascular diseases (CVDs) are the leading cause of death in Latin America and the Caribbean (LAC) region as well as worldwide. Lifestyle, nutritional habits and the upsurge of obesity have contributed to the increase in the prevalence of CVDs in the region. The role of nuclear cardiology in the management of patients with CVDs is well established. Particularly, myocardial perfusion imaging is widely used in LAC countries and has been increasingly integrated into the healthcare systems in the region for the diagnosis of coronary artery disease, risk stratification and to guide patient management. In its role to support countries around the world to address their health needs through the peaceful applications of nuclear techniques, the International Atomic Energy Agency (IAEA) has provided assistance to the LAC region for the establishment and strengthening of the nuclear cardiology practice. To that extent, the IAEA provides support in building capacities of multidisciplinary teams of professionals, the provision of medical equipment and the promotion of communication and exchange of knowledge among the different stakeholders. In addition, the IAEA encourages the participation of nuclear medicine centers in international multi-center research studies. In this paper, we present some of the projects through which the IAEA has supported the LAC region, including regional technical cooperation projects and coordinated research projects related to cardiology within the current multimodality approach to cardiac imaging.

Uso adecuado de las pruebas no invasivas de isquemia para guiar la toma de decisión sobre revascularización tras un infarto agudo de miocardio con elevación del segmento ST en países iberoamericanos: Resultados de la reunión de un panel de expertos de la International Atomic Energy Agency / Appropriate use of noninvasive ischemia testing to guide revascularization decision making following acute ST elevation myocardial infarction in Latin American countries: Results from an expert panel meeting of the International Atomic Energy Agency

En los países iberoamericanos y caribeños las cardiopatías, y en especial las cardiopatías isquémicas, constituyen la causa principal de muerte tanto en varones como en mujeres. En muchos de estos países los esfuerzos sobre salud pública y comunitaria tratan de definir las estrategias de cuidados que sean efectivas desde los puntos de vista clínico y de costes, promuevan la prevención primaria y secundaria, y redunden en la mejora de los resultados de los pacientes. El enfoque óptimo para el tratamiento de episodios agudos tales como el infarto de miocardio con elevación del segmento ST (IAMCEST) es una cuestión controvertida; sin embargo, el papel de la valoración de la carga isquémica residual en los pacientes de IAMCEST tras una intervención coronaria percutánea primaria se encuentra en expansión. Aunque los ensayos clínicos aleatorizados han establecido el valor de la revascularización guiada por la reserva de flujo fraccional escalonada, el uso de técnicas de imagen funcionales no invasivas puede jugar un papel similar a mucho menor coste. Para los pacientes iberoamericanos y caribeños, podrían aplicarse las técnicas disponibles de imágenes de estrés para definir la isquemia residual en la arteria no infartada y orientar la revascularización en un procedimiento escalonado tras una intervención coronaria percutánea primaria. El uso de imagen cardíaca nuclear, respaldado por su disponibilidad relativamente amplia, coste moderado y capacidades cuantitativas sólidas, puede servir de guía a una atención efectiva y reducir los episodios cardíacos subsiguientes en pacientes con cardiopatía coronaria. Esta técnica no invasiva puede evitar las cuestiones de seguridad potenciales de los procedimientos invasivos prolongados y repetidos, y servir de referencia para las pruebas subsiguientes de estrés tras el episodio de IAMCEST inicial. Este documento de consenso fue diseñado por la reunión del panel de expertos de la International Atomic Energy Agency y destaca la evidencia disponible centrada en la utilidad de la imagen de perfusión miocárdica de estrés en pacientes post-IAMCEST. El documento podría servir como guía para el uso prudente y adecuado de la imagen nuclear orientada a la gestión terapéutica, a fin de evitar los procedimientos invasivos innecesarios en los países iberoamericanos y caribeños, en los que los recursos podrían ser escasos

Across Latin American and Caribbean countries, cardiovascular disease and especially ischemic heart disease is currently the main cause of death both in men and in women. For most Latin American and Caribbean countries, public and community health efforts aim to define care strategies which are both clinically and cost effective and promote primary and secondary prevention, resulting in improved patient outcomes. The optimal approach to deal with acute events such as ST-elevation myocardial infarction (STEMI) is a matter of controversy; however, there is an expanding role for assessing residual ischemic burden in STEMI patients following primary percutaneous coronary intervention. Although randomized clinical trials have established the value of staged fractional flow reserve-guided revascularization, the use of noninvasive functional imaging modalities may play a similar role at a much lower cost. For LAC, available stress imaging techniques could be applied to define residual ischemia in the non-infarct related artery and to target revascularization in a staged procedure after primary percutaneous coronary intervention The use of nuclear cardiac imaging, supported by its relatively wide availability, moderate cost, and robust quantitative capabilities, may serve to guide effective care and to reduce subsequent cardiac events in patients with coronary artery disease. This noninvasive approach may avert potential safety issues with repeat and lengthy invasive procedures, and serve as a baseline for subsequent follow-up stress testing following the index STEMI event. This consensus document was devised from an expert panel meeting of the International Atomic Energy Agency, highlighting available evidence with a focus on the utility of stress myocardial perfusion imaging in post-STEMI patients. The document could serve as guidance to the prudent and appropriate use of nuclear imaging for targeting therapeutic management and avoiding unnecessary invasive procedures within Latin American and Caribbean countries, where resources could be scarce

Appropriate use of noninvasive ischemia testing to guide revascularization decision making following acute ST elevation myocardial infarction in Latin American countries: Results from an expert panel meeting of the International Atomic Energy Agency. / Uso adecuado de las pruebas no invasivas de isquemia para guiar la toma de decisión sobre revascularización tras un infarto agudo de miocardio con elevación del segmento ST en países iberoamericanos: Resultados de la reunión de un panel de expertos de la International Atomic Energy Agency.

Across Latin American and Caribbean countries, cardiovascular disease and especially ischemic heart disease is currently the main cause of death both in men and in women. For most Latin American and Caribbean countries, public and community health efforts aim to define care strategies which are both clinically and cost effective and promote primary and secondary prevention, resulting in improved patient outcomes. The optimal approach to deal with acute events such as ST-elevation myocardial infarction (STEMI) is a matter of controversy; however, there is an expanding role for assessing residual ischemic burden in STEMI patients following primary percutaneous coronary intervention. Although randomized clinical trials have established the value of staged fractional flow reserve-guided revascularization, the use of noninvasive functional imaging modalities may play a similar role at a much lower cost. For LAC, available stress imaging techniques could be applied to define residual ischemia in the non-infarct related artery and to target revascularization in a staged procedure after primary percutaneous coronary intervention The use of nuclear cardiac imaging, supported by its relatively wide availability, moderate cost, and robust quantitative capabilities, may serve to guide effective care and to reduce subsequent cardiac events in patients with coronary artery disease. This noninvasive approach may avert potential safety issues with repeat and lengthy invasive procedures, and serve as a baseline for subsequent follow-up stress testing following the index STEMI event. This consensus document was devised from an expert panel meeting of the International Atomic Energy Agency, highlighting available evidence with a focus on the utility of stress myocardial perfusion imaging in post-STEMI patients. The document could serve as guidance to the prudent and appropriate use of nuclear imaging for targeting therapeutic management and avoiding unnecessary invasive procedures within Latin American and Caribbean countries, where resources could be scarce.

Tratamiento quirúrgico de quistes dentígeros asociados a terceros molares: presentación de dos casos clínicos y revisión de la literatura / Surgical treatment of dentigerous cysts associated to third molars: two case reports and a literature review

Introducción. El quiste dentígero es un quiste odontógeno del desarrollo de origen epitelial, siendo el más común después del radicular. Generalmente se asocia con la corona de dientes permanentes impactados o no erupcionados y su aparición es más frecuente en varones durante la segunda década de la vida. Los dientes que suelen verse más afectados son los terceros molares mandibulares, seguido de los caninos maxilares. A causa de su curso asintomático, el diagnóstico suele realizarse por hallazgo casual en radiografías panorámicas rutinarias. Para el diagnóstico definitivo es indispensable la realización de la anatomía patológica. Caso clínico. Se presenta el caso clínico de dos mujeres de 60 y 42 años de edad, sin antecedentes médicos de interés, remitidas al servicio de Cirugía Bucal del hospital Virgen de la Paloma, presentando una imagen radiográfica radiotransparente asociada a la corona del tercer molar inferior izquierdo sin sintomatología asociada. Tras realizar la extracción quirúrgica de los cordales afectados y la lesión quística asociada, se obtiene el diagnóstico definitivo mediante la anatomía patológica, posteriormente se realizan controles clínicos y radiográficos de la zona. Conclusiones. El quiste dentígero representa el segundo quiste odontógeno más frecuente después del quiste radicular en terceros molares retenidos. Es importante el examen radiográfico periódico de terceros molares incluidos para el diagnóstico y tratamiento de esta entidad patológica (AU)

Introduction. A dentigerous cyst or follicular cyst is defined as a developmental odontogenic cyst of an epitelial origin which represents the second most common entity after the radicular cyst. Generally it is associated with the crown of a permanent unerupted tooth (or semi-erupted) and it tends to be more frequent in males during the second decade of life. The most common location of dentigerous cyst are mandibular third molars followed by the maxillary canines. Due to its asymptomatic behaviour, the diagnosis is reached by routine panoramic radiography, however, the anatomopathologic analysis will define its nature. Case Report. A case report of a 42 and 60 year old females with no medical history of interest, referred to the Oral Surgery Service of the hospital Virgen de la Paloma with a radiotransparent images surrounding the crown of the lower left third molar without associated symptoms. After the extraction of the teeth, cystic lessions are sent for anatomopathological study, which confirm the presumption diagnosis, dentigerous cyst. Patients carried out posterior follow ups sho-wing a positive healing of the bone around the surgical area. Conclusions. Dentigerous cyst represents the second most frequent odontogenic cyst after the radicular cyst at mandibular third lower molars. It is essential to monitor retained mandibular lower third molars for the incipient approach of the pathology (AU)

Exodoncia en pacientes geriátricos con bifosfonatos / Extraction in geriatric patients with phosphonates

En el paciente geriátrico, resulta común la presencia de enfermedades sistémicas, lo que conlleva a un consumo de diferentes fármacos para el tratamiento de las mismas. Uno de los más frecuentes son los bifosfonatos. Por lo general, los bifosfonatos son fármacos bien tolerados si se administran correctamente, aunque en los últimos años también se han descrito diferentes efectos adversos asociados a su consumo, siendo la osteonecrosis maxilar uno de los más importantes. Desde entonces son numerosos los casos publicados en los cuales se afirma que los procedimientos quirúrgicos menores como las exodoncias podrían ser uno de los factores desencadenantes. En el caso de los bifosfonatos intravenosos, dado que el riesgo es mucho mayor, se sugiere evitar en lo posible los tratamientos quirúrgicos orales como las extracciones mientras que en los tratamientos con bifosfonatos orales no se puede contraindicar dichos tratamientos de esa manera tan categórica Ante esta situación resulta evidente la necesidad de establecer unos protocolos definitivos encaminados a la prevención y tratamiento de esta posible complicación que pudiese acontecer (AU)

In geriatric patients is common the presence of systemic diseases, leading to a use of various drugs for the treatment thereof. One of the most common are the bisphosphonates. In general, bisphosphonates are well tolerated drugs if properly managed, although in recent years have also been described different adverse effects associated with its consumption, with the maxillary osteonecrosis one of the most important. Since then are numerous reported cases in which it is stated that minor surgical procedures such as extractions could be one of the triggers. In the case of intravenous bisphosphonates, since the risk is much higher, it is suggested to avoid possible oral surgical treatments like extractions while on treatment with oral bisphosphonates may not contraindicate such treatments that so categorically. In this situation the need to establish a definitive protocols aimed at the prevention and treatment of this possible complication that could happen is obvious (AU)

Epidemiology and treatment of adenoid cystic carcinoma of the minorsalivary glands: A meta-analytic study

Objectives: To evaluate the epidemiological aspects of adenoid cystic carcinoma (ACC) and to evaluate the differenttherapeutic possibilities as well as the percentage of survival.Study Design: A retrospective, meta-analytic, observational study was carried out by selecting a total of 13 articles,which provided a sample size of 263 cases of patients who had been diagnosed with ACC in the minorsalivary glands.Results: ACC was found to be more common among women (56.5%) and the average age at diagnosis was 55.26years old. The primary location of the tumor was in the palate in 57% of the cases, the predominant pattern beingcribiform. The treatment of choice was therapy combined with surgery and radiotherapy in 62.7% of the subjects.The overall survival rate was 70.76% and 56.76%, at 5 and 10 years respectively.Conclusions: Early detection of adenoid cystic carcinoma is necessary in order to enable making an earlier prognosis and thus enable a better quality of life for the patient (AU)

Immediate post-extraction implants subject to immediate loading: a meta-analytic study.

UNLABELLED: Since Brånemark first started developing its implant system, there has been a continuous and significant evolution in oral implantology through experimental and clinical research, and many of the concepts that were once considered valid have now become the subject of debate. The insertion of the implant immediately after extraction of the tooth to be substituted has now become the implant treatment of choice and is associated with preserving the bone structure and the gingival architecture, as well as with reducing the treatment time, which ultimately benefits the patient. OBJECTIVE: To evaluate the success rate of the immediate post-extraction implants (IPI) subject to immediate loading. STUDY DESIGN: A meta-analytic study was carried out on 659 immediate post-extraction implants obtained from a bibliographic review of 25 articles published within the last 9 years. RESULTS: We obtained a sample of 322 patients who had been treated with a total of 659 implants placed immediately following extraction. The mean age of the patients was 51 years old. A total of 441 implants were inserted in the maxilla, 152 in the mandible and 64 were placed in an unspecified location. The survival rate ranged between 85% and 100%. CONCLUSIONS: Immediate post-extraction implant treatment is an implant alternative with a survival rate similar to that of the conventional technique for implant placement and enables preserving both the bone structure and gingival architecture, as well as providing immediate functional loading, thus improving the quality of the treatment as far as the patient is concerned.

Fusión de un tercer molar mandibular con un cuarto molar supernumerario / Fusion of mandibular third molar with supernumerary fourth molar

La fusión dental es la unión de dos gérmenes dentales normalmenteseparados, mientras que la geminación se define como el intentode división de un único germen dental.La fusión y geminación de molares es poco frecuente en la dentición permanente.Describimos un caso clínico de un tercer molar inferior derecho fusionadoa un cuarto molar supernumerario en un paciente varón de 36 años queha presentado repetidos episodios de pericoronaritis. Tras el estudio radiológicose realiza la exodoncia del cordal semiincluido bajo anestesia local.Llevamos a cabo una revisión bibliográfica al respecto(AU)

Dental fusion is the union of two tooth buds that normallyare separated, while gemination is defined as an attempt by a singletooth bud to divide.The fusion and gemination of molars is uncommon in permanentteeth.We report a clinical case of a right lower third molar fused to asupernumerary fourth molar in a 36-year-old male patient withrepeated episodes of inflammation. After the radiologic study, thesemi-impacted third molar was extracted under local anesthesia.The literature was reviewed(AU)

Cutaneous hyperpigmentation induced by omeprazole mimicking ashy dermatosis.

BACKGROUND: Omeprazole has been associated with multiple adverse effects including skin reactions but, to date, cutaneous hyperpigmentation has not been described as an adverse effect of this drug. OBSERVATIONS: We describe a case of a 52-year-old Caucasian woman who developed skin hyperpigmentation in the upper trunk, mimicking ashy dermatosis, 2 months after initiating omeprazole treatment. Histopathologic examination of a skin biopsy taken from a pigmented macule showed dermal macrophages containing golden-brown granules, which also displayed a sulphur peak on energy-dispersive X-ray microanalysis. High-performance liquid chromatography (HPLC) and mass spectrometry were also performed on the drug and on a biopsy specimen revealing the same chromatograms as well as the same mass spectra. CONCLUSIONS: According to our results, omeprazole itself may induce cutaneous pigmentation and, to our knowledge, this is the first report of this finding.

[The role of PET-FDG in questionable diagnosis of relapse in the presence of radionecrosis of brain tumors]. / Papel de la PET-FDG ante la duda diagnóstica de recidiva frente a radionecrosis en tumores cerebrales.

INTRODUCTION: Although CT and MR are sensitive techniques for the detection of cerebral tumours, both have limitations in distinguishing between tumour relapse (TR) and post-treatment radionecrosis (RN). PATIENTS AND METHODS: In this study we have determined the usefulness of metabolic imaging with PET-FDG in such situations. We assessed 70 patients with CNS tumours (22 low grade astrocytomas, 25 high grade astrocytomas, 3 oligodendrogliomas, 13 metastatic tumours and 7 other tumours. All had been treated with radiotherapy and other treatments such as radiosurgery, chemotherapy or different types of surgery, and presented clinical pictures which made it necessary to decide the differential diagnosis of relapse or radionecrosis. RESULTS: In the PET-FDG study visual and semiquantitative analysis was done by SUV (Standardized Update Value). Confirmation of the findings was obtained in 44 cases (24 TR and 20 RN). MR was doubtful or inconclusive in most cases, whilst with PET correct diagnosis was made in all cases. CONCLUSIONS: Metabolic imaging with PET-FGD is better than anatomostructural imaging techniques for differential diagnosis between tumour relapse and radionecrosis in CNS tumours which have been treated. Prospective studies are necessary for evaluation of SUV as a factor for prognosis of survival.

[Environmental and biological control in a population exposed to isoflurane in the operating room]. / Control ambiental y biológico de una población expuesta a isoflurano en el quirófano.

OBJECTIVE: To measure the level of occupational exposure to isoflurane in the operating room, and to determine the relation between isoflurane concentration in atmospheric and exhaled air. PATIENTS AND METHODS: One hundred seventy-eight samples were obtained from 60 male and female subjects who work in the operating room of our hospital. To monitor workplace exposure we used passive diffusion samplers. Biological monitoring (isoflurane in exhaled air) was accomplished with standard adsorption tubes to collect exhaled air samples. Gases were thermically separated and analyzed by gas chromatography. RESULTS: Atmospheric isoflurane concentrations ranged between 1.14 and 157.23 mg/m3 (geometric mean 16.23 mg/m3). Exhaled isoflurane concentrations ranged from 0.15 to 26.09 mg/m3 (geometric mean 2.85 mg/m3). Atmospheric and exhaled isoflurane concentrations were strongly related (r = 0.82; p < 0.0001). Linearity was determined by the following equation: log of exhaled isoflurane concentration = -0.69 + 0.95 log of atmospheric isoflurane concentration. CONCLUSIONS: The concentrations of isoflurane in atmospheric and exhaled air found in our study exceed the maximum levels for halogenated gases recommended by the National Institute for Occupational Safety and Health, although they do not exceed the levels stipulated by Swiss authorities. In order to adequately assess operating room antipollution measures, atmospheric and biologic monitoring of isoflurane and other inhaled anesthetic gas concentrations is necessary.

Intraoperative radiation therapy in malignant glioma: early clinical results.

Intraoperative radiation therapy (IORT) with high energy electron beams is a treatment modality that has been included in multimodal programs in oncology to improve local tumor control. From August 1991 to December 1993, 17 patients with primary (8) or recurrent (9) high grade malignant gliomas, anaplastic astrocytoma (4), anaplastic oligodendroglioma (6) and glioblastoma multiforme (7), underwent surgical resection and a single dose of 10-20 Gy intraoperative radiation therapy was delivered in tumor bed. Fourteen patients received either pre-operative (8) or post-operative (6) external beam radiation therapy. Primary gliomas: 18-months actuarial survival rate has been 56% (range: 1-21+ months) and the median survival time has not yet been achieved. Four patients developed tumor progression (median time to tumor progression: 9 months). Recurrent gliomas: 18-months actuarial survival rate and median survival time has been 47% and 13 months (range: 6-32+ months) respectively. The median time to tumor progression was 11 months. No IORT related mortality has been observed. IORT is an attractive, tolerable and feasible treatment modality as antitumoral intensification procedure in high grade malignant gliomas.